Mst1 shuts off cytosolic antiviral defense through IRF3 phosphorylation
نویسندگان
چکیده
منابع مشابه
PPM1A silences cytosolic RNA sensing and antiviral defense through direct dephosphorylation of MAVS and TBK1
Cytosolic RNA sensing is a prerequisite for initiation of innate immune response against RNA viral pathogens. Signaling through RIG-I (retinoic acid-inducible gene I)-like receptors (RLRs) to TBK1 (Tank-binding kinase 1)/IKKε (IκB kinase ε) kinases is transduced by mitochondria-associated MAVS (mitochondrial antiviral signaling protein). However, the precise mechanism of how MAVS-mediated TBK1/...
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ژورنال
عنوان ژورنال: Genes & Development
سال: 2016
ISSN: 0890-9369,1549-5477
DOI: 10.1101/gad.277533.116